Post-Doc position (organic chemistry and photophysics) – ICMUB – Dijon
Contexte et mission :
The candidate will be recruited by the Université de Bourgogne and his/her research will be conducted within the context of an European project named « CoDaFlight » and led by a cross-disciplinary consortium (electronic and biomedical-engineers, physicists, chemists, medical scientists, and clinicians). The primary goal of this project is to develop a cutting-edge approach for multi-domain fluorescence imaging based on lifetime measurements , to address challenges in medical diagnosis.
Specifically, the aim of the post-doc work is to design, synthesize and perform structural optimization of emerging/promising classes of NIR-emissive organic-based fluorophores, especially derived from those developed in our group (Bodipys or aza-Bodipys , diketopyrrolopyrroles (DPPs) ), that will be used as lifetime-tunable fluorescent contrast agents. Ability of these novel fluorescent markers to act as effective biolabeling reagents and/or valuable scaffolds for the construction of bioanalyte-responsive fluorogenic probes, will also be explored.
Candidate profile :
Ph.D. in organic chemistry with a good theoretical and practical knowledge in photophysics, truly interested in organic synthesis and analytical chemistry, in particular the chromatographic techniques (semi-preparative HPLC, HPLC-MS, …) and advanced spectroscopic techniques (steady-state and time-resolved fluorescence, …). Rigor and care in the experimental work (small scale syntheses, handling of high added-value compounds, …), proactive attitude towards problem solving and scientific watch, acute sense of ethics and organization, and good drafting/communication skills are required. A first meaningful research experience in chemistry and photophysics of fluorophores and/or « smart » fluorescent probes, may be a valuable asset but not mandatory.
Application documents : detailed CV (+ 2-3 references), a brief summary of research works and a detailed covering letter.
Please visit website of the analytical platform PACSMUB :
http://wpcm.fr/index.php?page=presentation-generale
Structure :
Our research group at ICMUB lab. (UMR 6302, Univ. Bourgogne Franche-Comté, CNRS, Dijon, http://www.icmub.com/), recognized as one of the leading French academic players in the field of « Chemistry for Molecular Imaging », is offering a 24-month post-doc position (preferred starting date: October 2022).