FLI
In this section, you will find internships, thesis, post-doctorates, fixed-term and permanent contract vacancies in the network’s partner laboratories.
Liste des annonces
2016/09/29 Post-doctoral position on the LONGIDEP study, Rennes
LONGIDEP is a routine care cohort of patients suffering from mood depressive disorder (MDD) who underwent clinical, neuropsychological and imaging. The aims of this study are 1/ to identify clinical and imaging markers (morphological and arterial spin labeling-resting state perfusion) which are predictive of pejorative outcome in MDD and 2/ to identify pathophysiological processes involved in MDD at different resistance stages in order to better characterize them.
The objective of this post-doc position will be to use available and develop new image processing methods in order to identify imaging biomarkers that can correlate indices coming from the imaging data with clinical scores. The post-doc will work on the LONGIDEP clinical protocol that measures both structural state of the brain using a combination of MRI sequences such as Arterial Spin Labeling and high resolution diffusion MRI (for multi-compartment diffusion imaging).
This will require software integration for:
1. Image processing of morphological data (voxel-based morphometry, anatomical connectivity based on DTI), arterial spin labeling (pulsed and pseudo-continuous), individual imaging patterns. This part will be driven by the daily close collaboration between clinicians and post-doctoral researcher.
2. Data analysis for the study of functional ASL-based connectivity.
From a methodological perspective, this work will deal with
- registration between modalities, (intra- and inter-subjects)
- segmentation of the brain compartments
- quantification of brain perfusion and image artefacts correction
- modeling of diffusion MRI data
- statistical comparisons between imaging and clinical scores
The post-doc will work in close collaboration with PhD students, already working on the project and in charge of recruiting the control subjects and patients. At least two articles are expected from this research program.
Duration: 1 year with possible renewal
Keywords: Medical Image Processing, Neuroimaging, Statistical Analysis
2016/09/29 Post-doctoral position in spinal cord MR analysis methods and markers, Rennes
An ongoing national longitudinal multicenter study, lead by Rennes, is investigating the link between spinal cord MR imaging and ambulatory disabilities (EMISEP). To date, most of the many MRI studies have focused on brain MRI but interest in spinal cord MRI is growing. Advanced spinal cord MR imaging remains challenging due to the small volume of the cord as well as to respiratory and
cardiac motion. Several MRI sequences are acquired each year, as part of the EMISEP imaging protocol, to visualize focal lesions, evaluate spinal cord volume or diffuse lesions using diffusion and magnetization transfer imaging.
The main goal of this post-doctoral position will be to develop and evaluate new methods for spinal cord MR analysis and derive markers of spinal cord burden related to ambulatory disability. Therefore, the work will encompass several methodological tasks starting with registration between different MR sequences and between different time points in the same subject, and between different subjects at a given time point. This work will, among others, rely on methods developed in the research team.
The second challenge will be devoted to the extraction of regions of interest in the spinal cord, whether white matter, gray matter, lesions or spinal cord tracts, using tools available from the literature or adapted from similar tasks on brain MRI for this purpose.
The post-doctorate will further use all these tools to process the EMISEP database in order to evaluate both focal and diffuse burden as well as their evolution in time. The correlation between these markers and clinical scores acquired in parallel will then be investigated.
From a methodological perspective, this work will deal with
• registration between modalities, time points and patients
• segmentation of the spinal cord and MS lesions
• distortion correction
• statistical comparisons between imaging and clinical scores
Duration: One year, renewable, starting from September 2016
2016/09/29 Post-doctoral position in spinal cord MR analysis methods and markers, Rennes
An ongoing national longitudinal multicenter study, lead by Rennes, is investigating the link between spinal cord MR imaging and ambulatory disabilities (EMISEP). To date, most of the many MRI studies have focused on brain MRI but interest in spinal cord MRI is growing. Advanced spinal cord MR imaging remains challenging due to the small volume of the cord as well as to respiratory and
cardiac motion. Several MRI sequences are acquired each year, as part of the EMISEP imaging protocol, to visualize focal lesions, evaluate spinal cord volume or diffuse lesions using diffusion and magnetization transfer imaging.
The main goal of this post-doctoral position will be to develop and evaluate new methods for spinal cord MR analysis and derive markers of spinal cord burden related to ambulatory disability. Therefore, the work will encompass several methodological tasks starting with registration between different MR sequences and between different time points in the same subject, and between different subjects at a given time point. This work will, among others, rely on methods developed in the research team.
The second challenge will be devoted to the extraction of regions of interest in the spinal cord, whether white matter, gray matter, lesions or spinal cord tracts, using tools available from the literature or adapted from similar tasks on brain MRI for this purpose.
The post-doctorate will further use all these tools to process the EMISEP database in order to evaluate both focal and diffuse burden as well as their evolution in time. The correlation between these markers and clinical scores acquired in parallel will then be investigated.
From a methodological perspective, this work will deal with
• registration between modalities, time points and patients
• segmentation of the spinal cord and MS lesions
• distortion correction
• statistical comparisons between imaging and clinical scores
Duration: One year, renewable, starting from September 2016
2016/09/19 Chef de projet pour le réseau REMI
CDD 1 an temps plein. Démarrage au plus tard au 1/1/2017
Le chef de projet aura pour mission d'aider à la mise en place de ce réseau académique d'entraide, que ce soit sur les aspects outils, organisation ou communication.
• Soutien à la création d’un réseau IRM académique d’entraide
• Animation du réseau et des relations externes
• Suivi et participation aux groupes de travail (bonnes pratiques, suivi qualité machine, ...)
• Soutien à la mise en place et à la maintenance du site web
• Organisation des rencontres dans les congrès français (JFR, SFRMBM, AFPPE, ...)
• Recensement des besoins pour les études méthodologiques
Compétences / connaissances
• Connaissances sur les principes physiques de l’IRM
• Connaissance de la recherche clinique en imagerie
• Des connaissances ou un intérêt pour le design de site web seraient un plus
• Compréhension de l’anglais scientifique
Savoir être
• Facilité de contact
• Capacité d’écoute
• Capacité de synthèse et de rédaction
• Capacité d’organisation et rigueur
• Autonomie
2016/09/19 Chef de projet pour le réseau REMI
CDD 1 an temps plein. Démarrage au plus tard au 1/1/2017
Le chef de projet aura pour mission d'aider à la mise en place de ce réseau académique d'entraide, que ce soit sur les aspects outils, organisation ou communication.
• Soutien à la création d’un réseau IRM académique d’entraide
• Animation du réseau et des relations externes
• Suivi et participation aux groupes de travail (bonnes pratiques, suivi qualité machine, ...)
• Soutien à la mise en place et à la maintenance du site web
• Organisation des rencontres dans les congrès français (JFR, SFRMBM, AFPPE, ...)
• Recensement des besoins pour les études méthodologiques
Compétences / connaissances
• Connaissances sur les principes physiques de l’IRM
• Connaissance de la recherche clinique en imagerie
• Des connaissances ou un intérêt pour le design de site web seraient un plus
• Compréhension de l’anglais scientifique
Savoir être
• Facilité de contact
• Capacité d’écoute
• Capacité de synthèse et de rédaction
• Capacité d’organisation et rigueur
• Autonomie
2016/09/08 Post-doctorat en physique de l’IRM et développement de Biomarqueurs, Paris
Un poste de post‐doctorant est ouvert pour 18 mois à temps plein au Centre de Neuroimagerie de Recherche (CENIR) à l’ICM (Paris) dans le cadre d’un projet financé par l’IHU‐A‐ICM (Projet « MAXIMS », Big Brain Theory, Janvier 2016).
L’objectif de ce projet est d’évaluer la spécificité de nouveaux biomarqueurs IRM de la microstructure de la matière blanche avec des validations histologiques et de microscopie électronique chez des modèles expérimentaux d’axonopathie et de myélinopathie.
Le CENIR est la plate-forme de neuroimagerie de l’ICM dirigée par le Pr. Stéphane Lehéricy. Ce plateau technologique est constitué notamment d’IRM cliniques (3T), d’une IRM expérimentale (Bruker Biospec 117/16 USR), ainsi que de systèmes MEG, EEG, TMS et TEP/IRM pour l’étude de la structure et fonction du cerveau dans des conditions saines ou pathologiques.
Le projet global implique des collaborations transversales entre experts en modélisations mathématiques, imagerie par IRM, imagerie cellulaire et histologie au sein et à l’extérieur de l’Institut. Une collaboration étroite est établie entre le CENIR et le groupe « Athena » de l’INRIA (Sophia‐Antipolis, France) dirigé par le Pr. Richard Deriche.
Le post‐doctorant sera impliqué dans les développements méthodologiques de nouveaux biomarqueurs de la matière blanche en IRM de diffusion et en diffusion spectroscopique. Dans ce cadre, le candidat sera en charge des acquisitions et des analyses des données à 11.7T chez des modèles rongeur d’axonopathie et myélinopathie. Le candidat sera potentiellement aussi impliqué dans les analyses de données de microscopie électronique ainsi que d’établir des corrélations avec les données IRM.
2016/09/08 Post-doctorat en physique de l’IRM et développement de Biomarqueurs, Paris
Un poste de post‐doctorant est ouvert pour 18 mois à temps plein au Centre de Neuroimagerie de Recherche (CENIR) à l’ICM (Paris) dans le cadre d’un projet financé par l’IHU‐A‐ICM (Projet « MAXIMS », Big Brain Theory, Janvier 2016).
L’objectif de ce projet est d’évaluer la spécificité de nouveaux biomarqueurs IRM de la microstructure de la matière blanche avec des validations histologiques et de microscopie électronique chez des modèles expérimentaux d’axonopathie et de myélinopathie.
Le CENIR est la plate-forme de neuroimagerie de l’ICM dirigée par le Pr. Stéphane Lehéricy. Ce plateau technologique est constitué notamment d’IRM cliniques (3T), d’une IRM expérimentale (Bruker Biospec 117/16 USR), ainsi que de systèmes MEG, EEG, TMS et TEP/IRM pour l’étude de la structure et fonction du cerveau dans des conditions saines ou pathologiques.
Le projet global implique des collaborations transversales entre experts en modélisations mathématiques, imagerie par IRM, imagerie cellulaire et histologie au sein et à l’extérieur de l’Institut. Une collaboration étroite est établie entre le CENIR et le groupe « Athena » de l’INRIA (Sophia‐Antipolis, France) dirigé par le Pr. Richard Deriche.
Le post‐doctorant sera impliqué dans les développements méthodologiques de nouveaux biomarqueurs de la matière blanche en IRM de diffusion et en diffusion spectroscopique. Dans ce cadre, le candidat sera en charge des acquisitions et des analyses des données à 11.7T chez des modèles rongeur d’axonopathie et myélinopathie. Le candidat sera potentiellement aussi impliqué dans les analyses de données de microscopie électronique ainsi que d’établir des corrélations avec les données IRM.
2016/09/02 Post-doctoral position : Diffusion-weighted MR spectroscopy methods to measure brain metabolites diffusion
The present offer is for a post-doctoral position in MIRCen’s magnetic resonance group. Position is funded by a grant from the European Research Council (INCELL project, PI: Julien Valette). It is available now and secured until November 2018. The post-doc will work in close collaboration with the PI on the development of diffusion-weighted MRS strategies to measure brain metabolite diffusion over several orders of magnitude of diffusion time, in order to explore brain intracellular compartments over vastly different spatial scales. In particular, the potential of long-lived spin states and 13C-labeled metabolites with long T1 will be investigated to reach diffusion times up to ~10 seconds. The post-doc will also work on the development of diffusion-weighted spectroscopic imaging.
Methods will be evaluated in the healthy rodent brain, including advanced data modeling as developed in the group to extract information about cellular morphology, and comparison with confocal microscopy data. Methods will then be applied in rodent models of neurodegeneration to assess cellular alterations.
2016/08/31 PhD student in protease imaging by Dynamic Nuclear Polarization, Bordeaux
TITLE : In vivo proteolysis mapping using Overhauser-enhanced MRI
Proteases, tightly regulated under physiological conditions, become overexpressed in several situations. Any non-invasive tools are welcome to understand such processes in vivio, both for their fundamental features and for diagnosis of related diseases.
The project deals with molecular imaging and is at the crossroad of developmental physics, biochemistry and medicine. The work to be performed is two-fold. First, DNP-NMR (Magnetic Resonance enhanced by Dynamic Polarization) developments are still needed to enhance imaging performance (image quality and acquisition time). MRI sequence developments in acquisition and reconstruction are expected. Second, new DNP-MRI-visible nitroxide probes (developed in collaboration) shall be evaluated for their targeting of certain proteases that can occur in various diseases (cancer, inflammation). The goal is then to target in vivo abnormal proteolysis through DNP-MRI.
2016/08/31 PhD student in protease imaging by Dynamic Nuclear Polarization, Bordeaux
TITLE : In vivo proteolysis mapping using Overhauser-enhanced MRI
Proteases, tightly regulated under physiological conditions, become overexpressed in several situations. Any non-invasive tools are welcome to understand such processes in vivio, both for their fundamental features and for diagnosis of related diseases.
The project deals with molecular imaging and is at the crossroad of developmental physics, biochemistry and medicine. The work to be performed is two-fold. First, DNP-NMR (Magnetic Resonance enhanced by Dynamic Polarization) developments are still needed to enhance imaging performance (image quality and acquisition time). MRI sequence developments in acquisition and reconstruction are expected. Second, new DNP-MRI-visible nitroxide probes (developed in collaboration) shall be evaluated for their targeting of certain proteases that can occur in various diseases (cancer, inflammation). The goal is then to target in vivo abnormal proteolysis through DNP-MRI.